Synthetic Strategies with C1 Building Blocks in Flow

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Anastasios Polyzos (a,b)

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(a) School of Chemistry, The University of Melbourne, Victoria, Australia; (b) CSIRO Manufacturing, Victoria, Australia

 Associate Professor

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The synthesis of complex organic molecules from C1 compounds derived from biomass and CO2, such as CO, CH3OH, and CH4, is an important step towards a net-zero carbon future. This ambition requires a step change in synthetic methodology allowing the efficient installation of C1 compounds into inert starting materials to furnish advanced materials and intermediates, en route to the synthesis of complex targets such a pharmaceutical products, and even their late-stage functionalisation. Here we disclose the invention of protocols that combine visible light photoredox catalysis and electrosynthesis with flow chemistry for new carbonylative (CO) and carboxylation (CO2) reactions that generate diverse amide1, carboxylic acid and ketone2 products. Central to this approach is multiphoton photoredox catalysis3, and electrochemical methods that significantly expanding potential scope of C1 compounds in chemical synthesis, including complex target synthesis, and the generation of pharmaceuticals.

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Keywords:

radicals, carbanion, gas-liquid