Micro Space Synthesis Towards Fast Chemical Production

​

Ilhyong Ryu (a,b)

​

(a) Organization for Research Promotion, Osaka Metropolitan University (OMU), Sakai, Osaka 599-8531, Japan & (b) Department of Applied Chemistry, National Yang Ming Chiao Tung University (NYCU), Hsinchu 30010, Taiwan

​

Flow chemistry has found growing applications in the pharmaceutical and chemical industries.  Behind each success no doubt the information accumulated by micro space reactions contributes.   In this lecture, I would like to discuss our recent efforts to develop the flow unit reactions having an industrial potential including photo flow reactions.[1] I also discuss a topic on ultra minimum organic synthesis, in which we rely on a droplet as microreactor space. In Figure 1, the condensation leading to flutolanil, a systemic fungicide supplied from Nihon Nohyaku Co. Ltd. by droplet reaction is given.

​

​

​

​

​

​

​

​

​

​

Figure 1.  (A) Single droplet generation.  (B) Condensation Reaction Leading to Flutolanil Using a Droplet as a Microreactor

 

References

[1]  T. Fukuyama; T. Kasakado, M. Hyodo, I. Ryu, Photochem. Photobiol. Sci. 2022, 21, 761–775.T. Kasakado, T. Fukuyama, T. Nakagawa, S. Taguchi, I. Ryu, Beilstein J. Org. Chem. 2022, 18 , 152-158. T. Kasakado, Y. Hirobe, A. Furuta, M. Hyodo, T. Fukuyama, I. Ryu, Molecules 2021, 26, 5845-5853. Y. -L. Shih, Y. -K. Wu, M. Hyodo, I. Ryu, J. Org. Chem. 2023, 88 , 6548-6552.

 

Keywords: droplet, photocatalyst, flow production

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​